Path ID: DB00704_MESH_D000437_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D009270 | Naltrexone | Drug |
| UniProt:P41145 | Kappa-type opioid receptor | Protein |
| UniProt:P01213 | Proenkephalin-B | Protein |
| HP:0030858 | Addictive behavior | PhenotypicFeature |
| UniProt:P41143 | Delta-type opioid receptor | Protein |
| UniProt:P35372 | Mu-type opioid receptor | Protein |
| GO:0061527 | Dopamine secretion, neurotransmission | BiologicalProcess |
| MESH:D000437 | Alcoholism | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Naltrexone | DECREASES ACTIVITY OF | Kappa-Type Opioid Receptor |
| Kappa-Type Opioid Receptor | MOLECULARLY INTERACTS WITH | Proenkephalin-B |
| Proenkephalin-B | POSITIVELY CORRELATED WITH | Addictive Behavior |
| Naltrexone | DECREASES ACTIVITY OF | Delta-Type Opioid Receptor |
| Delta-Type Opioid Receptor | POSITIVELY CORRELATED WITH | Dopamine Secretion, Neurotransmission |
| Naltrexone | DECREASES ACTIVITY OF | Mu-Type Opioid Receptor |
| Mu-Type Opioid Receptor | POSITIVELY CORRELATED WITH | Dopamine Secretion, Neurotransmission |
| Dopamine Secretion, Neurotransmission | POSITIVELY CORRELATED WITH | Addictive Behavior |
| Addictive Behavior | OCCURS IN | Alcoholism |
Reference: