Path ID: DB00703_MESH_D005902_1

db00703-mesh-d005902-1

Concepts

Identifier Name Type
MESH:D008704 Methazolamide Drug
UniProt:P00915 Carbonic anhydrase 1 Protein
UniProt:P00918 Carbonic anhydrase 2 Protein
UniProt:P07451 Carbonic anhydrase 3 Protein
UniProt:P22748 Carbonic anhydrase 4 Protein
UniProt:P43166 Carbonic anhydrase 7 Protein
GO:0015701 bicarbonate transport BiologicalProcess
UBERON:0001796 aqueous humor of eyeball GrossAnatomicalStructure
HP:0007906 Ocular hypertension PhenotypicFeature
MESH:D005902 Glaucoma, Open-Angle Disease

Relationships

NOTE: predicates are annotated in Biolink Model (v1.3.0)

Subject Predicate Object
Methazolamide NEGATIVELY REGULATES Carbonic Anhydrase 1
Methazolamide NEGATIVELY REGULATES Carbonic Anhydrase 2
Methazolamide NEGATIVELY REGULATES Carbonic Anhydrase 3
Methazolamide NEGATIVELY REGULATES Carbonic Anhydrase 4
Methazolamide NEGATIVELY REGULATES Carbonic Anhydrase 7
Carbonic Anhydrase 1 POSITIVELY REGULATES Bicarbonate Transport
Carbonic Anhydrase 2 POSITIVELY REGULATES Bicarbonate Transport
Carbonic Anhydrase 3 POSITIVELY REGULATES Bicarbonate Transport
Carbonic Anhydrase 4 POSITIVELY REGULATES Bicarbonate Transport
Carbonic Anhydrase 7 POSITIVELY REGULATES Bicarbonate Transport
Bicarbonate Transport INCREASES ABUNDANCE OF Aqueous Humor Of Eyeball
Aqueous Humor Of Eyeball POSITIVELY CORRELATED WITH Ocular Hypertension
Ocular Hypertension MANIFESTATION OF Glaucoma, Open-Angle

Reference: