Path ID: DB00697_MESH_D009128_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C023754 | tizanidine | Drug |
| UniProt:P08913 | Alpha-2A adrenergic receptor | Protein |
| UniProt:P18825 | Alpha-2C adrenergic receptor | Protein |
| UniProt:P18089 | Alpha-2B adrenergic receptor | Protein |
| HP:0003394 | Muscle spasm | PhenotypicFeature |
| MESH:D009128 | Spasticity | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Tizanidine | INCREASES ACTIVITY OF | Alpha-2A Adrenergic Receptor |
| Tizanidine | INCREASES ACTIVITY OF | Alpha-2C Adrenergic Receptor |
| Tizanidine | INCREASES ACTIVITY OF | Alpha-2B Adrenergic Receptor |
| Alpha-2A Adrenergic Receptor | NEGATIVELY CORRELATED WITH | Muscle Spasm |
| Alpha-2C Adrenergic Receptor | NEGATIVELY CORRELATED WITH | Muscle Spasm |
| Alpha-2B Adrenergic Receptor | NEGATIVELY CORRELATED WITH | Muscle Spasm |
| Muscle Spasm | POSITIVELY CORRELATED WITH | Spasticity |
Comment: The relation between the α2 receptor agonism and the spasmolytic action is still not fully understood (https://en.wikipedia.org/wiki/Tizanidine#Pharmacology).
Reference: