Path ID: DB00696_MESH_D014653_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D004878 | ergotamine | Drug |
| UniProt:P28221 | 5-hydroxytryptamine receptor 1D | Protein |
| UniProt:P35348 | Alpha-1A adrenergic receptor | Protein |
| UniProt:P08913 | Alpha-2A adrenergic receptor | Protein |
| UniProt:P18825 | Alpha-2C adrenergic receptor | Protein |
| UniProt:P25100 | Alpha-1D adrenergic receptor | Protein |
| UniProt:P35368 | Alpha-1B adrenergic receptor | Protein |
| UniProt:P18089 | Alpha-2B adrenergic receptor | Protein |
| MESH:D013373 | Substance P | ChemicalSubstance |
| GO:0006954 | inflammatory response | BiologicalProcess |
| GO:0042310 | vasoconstriction | BiologicalProcess |
| MESH:D014653 | Vascular headache | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Ergotamine | POSITIVELY REGULATES | Alpha-1A Adrenergic Receptor |
| Ergotamine | POSITIVELY REGULATES | Alpha-2A Adrenergic Receptor |
| Ergotamine | POSITIVELY REGULATES | Alpha-2C Adrenergic Receptor |
| Ergotamine | POSITIVELY REGULATES | Alpha-1D Adrenergic Receptor |
| Ergotamine | POSITIVELY REGULATES | Alpha-1B Adrenergic Receptor |
| Ergotamine | POSITIVELY REGULATES | Alpha-2B Adrenergic Receptor |
| Alpha-1A Adrenergic Receptor | POSITIVELY REGULATES | Vasoconstriction |
| Alpha-2A Adrenergic Receptor | POSITIVELY REGULATES | Vasoconstriction |
| Alpha-2C Adrenergic Receptor | POSITIVELY REGULATES | Vasoconstriction |
| Alpha-1D Adrenergic Receptor | POSITIVELY REGULATES | Vasoconstriction |
| Alpha-1B Adrenergic Receptor | POSITIVELY REGULATES | Vasoconstriction |
| Alpha-2B Adrenergic Receptor | POSITIVELY REGULATES | Vasoconstriction |
| Vasoconstriction | NEGATIVELY CORRELATED WITH | Vascular Headache |
| Ergotamine | POSITIVELY REGULATES | 5-Hydroxytryptamine Receptor 1D |
| 5-Hydroxytryptamine Receptor 1D | POSITIVELY REGULATES | Vasoconstriction |
| 5-Hydroxytryptamine Receptor 1D | DECREASES ABUNDANCE OF | Substance P |
| Substance P | POSITIVELY CORRELATED WITH | Inflammatory Response |
| Inflammatory Response | POSITIVELY CORRELATED WITH | Vascular Headache |
Reference: