Path ID: DB00695_MESH_D006973_1

Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D005665 | furosemide | Drug |
| UniProt:Q13621 | Solute carrier family 12 member 1 | Protein |
| GO:0070294 | Renal sodium ion reabsorption | BiologicalProcess |
| GO:0003092 | Renal water retention | BiologicalProcess |
| HP:0011104 | Abnormality of blood volume homeostasis | PhenotypicFeature |
| GO:0045777 | Positive regulation of blood pressure | BiologicalProcess |
| MESH:D006973 | Hypertensive disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Furosemide | DECREASES ACTIVITY OF | Solute Carrier Family 12 Member 1 |
| Solute Carrier Family 12 Member 1 | PARTICIPATES IN | Renal Sodium Ion Reabsorption |
| Renal Sodium Ion Reabsorption | POSITIVELY CORRELATED WITH | Renal Water Retention |
| Renal Water Retention | CONTRIBUTES TO | Abnormality Of Blood Volume Homeostasis |
| Abnormality Of Blood Volume Homeostasis | CONTRIBUTES TO | Positive Regulation Of Blood Pressure |
| Positive Regulation Of Blood Pressure | AFFECTS RISK FOR | Hypertensive Disorder |
Reference:
- https://go.drugbank.com/drugs/DB00695
- https://pubchem.ncbi.nlm.nih.gov/compound/3440
- https://en.wikipedia.org/wiki/Furosemide
- https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL35/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2014966/
- https://pubmed.ncbi.nlm.nih.gov/7230610/
- https://www.cell.com/trends/pharmacological-sciences/fulltext/0165-6147(87)90197-0