Path ID: DB00692_MESH_D016491_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D010646 | Phentolamine | Drug |
| UniProt:P35368 | Alpha-1B adrenergic receptor | Protein |
| UniProt:P35348 | Alpha-1A adrenergic receptor | Protein |
| UniProt:P25100 | Alpha-1D adrenergic receptor | Protein |
| GO:0042310 | Vasoconstriction | BiologicalProcess |
| HP:0000822 | Hypertension | PhenotypicFeature |
| MESH:D016491 | Peripheral vascular disease | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Phentolamine | DECREASES ACTIVITY OF | Alpha-1B Adrenergic Receptor |
| Phentolamine | DECREASES ACTIVITY OF | Alpha-1A Adrenergic Receptor |
| Phentolamine | DECREASES ACTIVITY OF | Alpha-1D Adrenergic Receptor |
| Alpha-1B Adrenergic Receptor | POSITIVELY REGULATES | Vasoconstriction |
| Alpha-1A Adrenergic Receptor | POSITIVELY REGULATES | Vasoconstriction |
| Alpha-1D Adrenergic Receptor | POSITIVELY REGULATES | Vasoconstriction |
| Vasoconstriction | AFFECTS RISK FOR | Hypertension |
| Hypertension | POSITIVELY CORRELATED WITH | Peripheral Vascular Disease |
Comment: Phentolamine primary action is vasodilation due to α1 blockade.
Reference: