Path ID: DB00691_MESH_D006973_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C058302 | moexipril | Drug |
| MESH:C059506 | moexiprilat | ChemicalSubstance |
| UniProt:P12821 | Angiotensin-converting enzyme | Protein |
| GO:0042310 | vasoconstriction | BiologicalProcess |
| GO:0035932 | aldosterone secretion | BiologicalProcess |
| GO:0045777 | positive regulation of blood pressure | BiologicalProcess |
| MESH:D006973 | Hypertension | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Moexipril | HAS METABOLITE | Moexiprilat |
| Moexiprilat | DECREASES ACTIVITY OF | Angiotensin-Converting Enzyme |
| Angiotensin-Converting Enzyme | POSITIVELY REGULATES | Vasoconstriction |
| Angiotensin-Converting Enzyme | POSITIVELY REGULATES | Aldosterone Secretion |
| Vasoconstriction | PARTICIPATES IN | Positive Regulation Of Blood Pressure |
| Aldosterone Secretion | PARTICIPATES IN | Positive Regulation Of Blood Pressure |
| Positive Regulation Of Blood Pressure | CONTRIBUTES TO | Hypertension |
Comment: Moexipril hydrochloride is a non-sulfhydryl of Moexipril, and acts as a prodrug of Moexiprilat.
Reference: