Path ID: DB00687_MESH_D000224_2
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C034635 | Fludrocortisone acetate | Drug |
| MESH:D005438 | Fludrocortisone | ChemicalSubstance |
| UniProt:P08235 | Mineralocorticoid receptor | Protein |
| GO:0070294 | Renal sodium ion absorption | BiologicalProcess |
| MESH:D012964 | Sodium | ChemicalSubstance |
| HP:0002632 | Blood pressure | PhenotypicFeature |
| GO:0070295 | Renal water absorption | BiologicalProcess |
| GO:0036359 | Renal potassium excretion | BiologicalProcess |
| MESH:D011188 | Potassium | ChemicalSubstance |
| HP:0002153 | Hyperkalemia | PhenotypicFeature |
| HP:0002615 | Hypotension | PhenotypicFeature |
| MESH:D000224 | Addison disease | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Fludrocortisone Acetate | HAS METABOLITE | Fludrocortisone |
| Fludrocortisone | INCREASES ACTIVITY OF | Mineralocorticoid Receptor |
| Mineralocorticoid Receptor | POSITIVELY CORRELATED WITH | Renal Sodium Ion Absorption |
| Renal Sodium Ion Absorption | INCREASES ABUNDANCE OF | Sodium |
| Sodium | NEGATIVELY CORRELATED WITH | Hypotension |
| Mineralocorticoid Receptor | POSITIVELY CORRELATED WITH | Renal Potassium Excretion |
| Renal Potassium Excretion | DECREASES ABUNDANCE OF | Potassium |
| Potassium | CONTRIBUTES TO | Hyperkalemia |
| Hyperkalemia | MANIFESTATION OF | Addison Disease |
| Mineralocorticoid Receptor | POSITIVELY CORRELATED WITH | Renal Water Absorption |
| Renal Water Absorption | POSITIVELY CORRELATED WITH | Blood Pressure |
| Blood Pressure | NEGATIVELY CORRELATED WITH | Hypotension |
| Hypotension | MANIFESTATION OF | Addison Disease |
Comment: Fludrocortisone acetate is a prodrug of fludrocortisone, a synthetic mineralocorticoid used in conjunction with hydrocortisone
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