Path ID: DB00685_MESH_D061387_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C080163 | Trovafloxacin | Drug |
| UniProt:Q9Z7I9 | DNA topoisomerase 4 subunit A (Chlamydial pneumoniae) | Protein |
| UniProt:Q54A16 | DNA gyrase subunit A (Chlamydial pneumoniae) | Protein |
| GO:0044787 | Bacterial-type DNA replication | BiologicalProcess |
| taxonomy:83558 | Chlamydial pneumoniae | OrganismTaxon |
| MESH:D061387 | Chlamydial pneumonia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Trovafloxacin | DECREASES ACTIVITY OF | Dna Topoisomerase 4 Subunit A (Chlamydial Pneumoniae) |
| Trovafloxacin | DECREASES ACTIVITY OF | Dna Gyrase Subunit A (Chlamydial Pneumoniae) |
| Dna Topoisomerase 4 Subunit A (Chlamydial Pneumoniae) | PARTICIPATES IN | Bacterial-Type Dna Replication |
| Dna Gyrase Subunit A (Chlamydial Pneumoniae) | PARTICIPATES IN | Bacterial-Type Dna Replication |
| Bacterial-Type Dna Replication | OCCURS IN | Chlamydial Pneumoniae |
| Chlamydial Pneumoniae | CAUSES | Chlamydial Pneumonia |
Comment: Due to its hepatotoxic potential, trovafloxacin was withdrawn from the market.
Reference: