Path ID: DB00685_MESH_D011023_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C080163 | Trovafloxacin | Drug |
| InterPro:IPR035516 | DNA gyrase/topoisomerase IV, subunit A, C-terminal | GeneFamily |
| InterPro:IPR013760 | DNA topoisomerase, type IIA-like domain superfamily | GeneFamily |
| GO:0006260 | Bacterial DNA replication | BiologicalProcess |
| taxonomy:1280 | Staphylococcus aureus | OrganismTaxon |
| MESH:D011023 | Staphylococcal pneumonia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Trovafloxacin | NEGATIVELY REGULATES | Dna Gyrase/Topoisomerase Iv, Subunit A, C-Terminal |
| Trovafloxacin | NEGATIVELY REGULATES | Dna Topoisomerase, Type Iia-Like Domain Superfamily |
| Dna Gyrase/Topoisomerase Iv, Subunit A, C-Terminal | POSITIVELY REGULATES | Bacterial Dna Replication |
| Dna Topoisomerase, Type Iia-Like Domain Superfamily | POSITIVELY REGULATES | Bacterial Dna Replication |
| Bacterial Dna Replication | IN TAXON | Staphylococcus Aureus |
| Staphylococcus Aureus | CAUSES | Staphylococcal Pneumonia |
Comment: Due to its hepatotoxic potential, trovafloxacin was withdrawn from the market.
Reference: