Path ID: DB00675_MESH_D018270_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D013629 | Tamoxifen | Drug |
| UniProt:P03372 | Estrogen receptor | Protein |
| GO:0030284 | Estrogen receptor activity | MolecularActivity |
| GO:0008283 | Cell population proliferation | BiologicalProcess |
| UniProt:Q92731 | Estrogen receptor beta | Protein |
| MESH:D018270 | Infiltrating duct carcinoma of breast | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Tamoxifen | DECREASES ACTIVITY OF | Estrogen Receptor |
| Estrogen Receptor | PARTICIPATES IN | Estrogen Receptor Activity |
| Estrogen Receptor Activity | POSITIVELY REGULATES | Cell Population Proliferation |
| Tamoxifen | DECREASES ACTIVITY OF | Estrogen Receptor Beta |
| Estrogen Receptor Beta | PARTICIPATES IN | Estrogen Receptor Activity |
| Cell Population Proliferation | POSITIVELY CORRELATED WITH | Infiltrating Duct Carcinoma Of Breast |
Comment: Tamoxifen is a selective estrogen receptor modulator used to treat estrogen receptor positive breast cancer.
Reference: