Path ID: DB00669_MESH_D003027_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D018170 | sumatriptan | Drug |
| UniProt:P28221 | 5-hydroxytryptamine receptor 1D | Protein |
| UniProt:P28222 | 5-hydroxytryptamine receptor 1B | Protein |
| GO:0042310 | vasoconstriction | BiologicalProcess |
| GO:0006954 | inflammatory response | BiologicalProcess |
| MESH:D003027 | Cluster headache syndrome | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Sumatriptan | POSITIVELY REGULATES | 5-Hydroxytryptamine Receptor 1D |
| Sumatriptan | POSITIVELY REGULATES | 5-Hydroxytryptamine Receptor 1B |
| 5-Hydroxytryptamine Receptor 1B | POSITIVELY REGULATES | Vasoconstriction |
| 5-Hydroxytryptamine Receptor 1D | NEGATIVELY REGULATES | Inflammatory Response |
| Inflammatory Response | POSITIVELY CORRELATED WITH | Cluster Headache Syndrome |
| Vasoconstriction | NEGATIVELY CORRELATED WITH | Cluster Headache Syndrome |
Reference: