Path ID: DB00668_MESH_D005902_3
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D004837 | epinephrine | Drug |
| UniProt:P08913 | Tumor necrosis factor | Protein |
| reactome:R-HSA-5357956 | TNFR1-induced NFkappaB signaling pathway | Pathway |
| reactome:R-HSA-5357786 | TNFR1-induced proapoptotic signaling | Pathway |
| GO:0006915 | apoptotic process | BiologicalProcess |
| MESH:D016923 | Cell Death | BiologicalProcess |
| CL:0000740 | retinal ganglion cell | Cell |
| MESH:D005902 | Open-angle glaucoma | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Epinephrine | DECREASES ACTIVITY OF | Tumor Necrosis Factor |
| Tumor Necrosis Factor | PARTICIPATES IN | Tnfr1-Induced Nfkappab Signaling Pathway |
| Tumor Necrosis Factor | PARTICIPATES IN | Tnfr1-Induced Proapoptotic Signaling |
| Tnfr1-Induced Nfkappab Signaling Pathway | POSITIVELY CORRELATED WITH | Cell Death |
| Tnfr1-Induced Proapoptotic Signaling | POSITIVELY CORRELATED WITH | Apoptotic Process |
| Cell Death | OCCURS IN | Retinal Ganglion Cell |
| Apoptotic Process | OCCURS IN | Retinal Ganglion Cell |
| Retinal Ganglion Cell | DISRUPTED BY | Open-Angle Glaucoma |
Reference: