Path ID: DB00668_MESH_D004417_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D004837 | Epinephrine | Drug |
| UniProt:P35348 | Alpha-1A adrenergic receptor | Protein |
| UniProt:P35368 | Alpha-1B adrenergic receptor | Protein |
| UniProt:P25100 | Alpha-1D adrenergic receptor | Protein |
| UniProt:P08913 | Alpha-2A adrenergic receptor | Protein |
| UniProt:P18089 | Alpha-2B adrenergic receptor | Protein |
| UniProt:P08588 | Beta-1 adrenergic receptor | Protein |
| UniProt:P07550 | Beta-2 adrenergic receptor | Protein |
| GO:0042310 | vasoconstriction | BiologicalProcess |
| UBERON:0001005 | respiratory airway | GrossAnatomicalStructure |
| MESH:D004417 | Dyspnea | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Epinephrine | INCREASES ACTIVITY OF | Alpha-1A Adrenergic Receptor |
| Epinephrine | INCREASES ACTIVITY OF | Alpha-1B Adrenergic Receptor |
| Epinephrine | DECREASES ACTIVITY OF | Alpha-1D Adrenergic Receptor |
| Epinephrine | INCREASES ACTIVITY OF | Alpha-2A Adrenergic Receptor |
| Epinephrine | INCREASES ACTIVITY OF | Alpha-2B Adrenergic Receptor |
| Epinephrine | INCREASES ACTIVITY OF | Beta-1 Adrenergic Receptor |
| Epinephrine | INCREASES ACTIVITY OF | Beta-2 Adrenergic Receptor |
| Alpha-1A Adrenergic Receptor | NEGATIVELY REGULATES | Vasoconstriction |
| Alpha-1B Adrenergic Receptor | NEGATIVELY REGULATES | Vasoconstriction |
| Alpha-1D Adrenergic Receptor | POSITIVELY REGULATES | Vasoconstriction |
| Alpha-2A Adrenergic Receptor | NEGATIVELY REGULATES | Vasoconstriction |
| Alpha-2B Adrenergic Receptor | NEGATIVELY REGULATES | Vasoconstriction |
| Beta-1 Adrenergic Receptor | NEGATIVELY REGULATES | Vasoconstriction |
| Beta-2 Adrenergic Receptor | NEGATIVELY REGULATES | Vasoconstriction |
| Vasoconstriction | LOCATED IN | Respiratory Airway |
| Respiratory Airway | LOCATION OF | Dyspnea |
Reference:
- https://go.drugbank.com/drugs/DB00668#mechanism-of-action
- https://en.wikipedia.org/wiki/Epinephrine_(medication)
- https://www.uniprot.org/uniprot/P35348#function
- https://www.uniprot.org/uniprot/P35368#function
- https://www.uniprot.org/uniprot/P25100#function
- https://www.uniprot.org/uniprot/P08913#function
- https://www.uniprot.org/uniprot/P18089#function
- https://www.uniprot.org/uniprot/P08588#function
- https://www.uniprot.org/uniprot/P07550#function
- https://en.wikipedia.org/wiki/Shortness_of_breath