Path ID: DB00668_MESH_D000707_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D004837 | epinephrine | Drug |
| UniProt:P35348 | Alpha-1A adrenergic receptor | Protein |
| UniProt:P35368 | Alpha-1B adrenergic receptor | Protein |
| UniProt:P25100 | Alpha-1D adrenergic receptor | Protein |
| UniProt:P07550 | Beta-2 adrenergic receptor | Protein |
| reactome:R-HSA-416476 | G alpha (q) signalling events | Pathway |
| reactome:R-HSA-416482 | G alpha (12/13) signalling events | Pathway |
| reactome:R-HSA-418555 | G alpha (s) signalling events | Pathway |
| GO:0042310 | vasoconstriction | BiologicalProcess |
| HP:0001025 | Urticaria | PhenotypicFeature |
| GO:0006939 | smooth muscle contraction | BiologicalProcess |
| GO:0002553 | histamine secretion by mast cell | BiologicalProcess |
| MESH:D000707 | Anaphylaxis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Epinephrine | INCREASES ACTIVITY OF | Alpha-1A Adrenergic Receptor |
| Epinephrine | INCREASES ACTIVITY OF | Alpha-1B Adrenergic Receptor |
| Epinephrine | INCREASES ACTIVITY OF | Alpha-1D Adrenergic Receptor |
| Epinephrine | INCREASES ACTIVITY OF | Beta-2 Adrenergic Receptor |
| Alpha-1D Adrenergic Receptor | PARTICIPATES IN | G Alpha (Q) Signalling Events |
| Alpha-1A Adrenergic Receptor | PARTICIPATES IN | G Alpha (Q) Signalling Events |
| Alpha-1B Adrenergic Receptor | PARTICIPATES IN | G Alpha (Q) Signalling Events |
| Alpha-1D Adrenergic Receptor | PARTICIPATES IN | G Alpha (12/13) Signalling Events |
| Alpha-1A Adrenergic Receptor | PARTICIPATES IN | G Alpha (12/13) Signalling Events |
| Alpha-1B Adrenergic Receptor | PARTICIPATES IN | G Alpha (12/13) Signalling Events |
| Beta-2 Adrenergic Receptor | PARTICIPATES IN | G Alpha (S) Signalling Events |
| G Alpha (S) Signalling Events | NEGATIVELY CORRELATED WITH | Smooth Muscle Contraction |
| G Alpha (S) Signalling Events | NEGATIVELY CORRELATED WITH | Histamine Secretion By Mast Cell |
| G Alpha (Q) Signalling Events | POSITIVELY REGULATES | Vasoconstriction |
| G Alpha (12/13) Signalling Events | POSITIVELY REGULATES | Vasoconstriction |
| Vasoconstriction | NEGATIVELY CORRELATED WITH | Urticaria |
| Urticaria | POSITIVELY CORRELATED WITH | Anaphylaxis |
| Histamine Secretion By Mast Cell | POSITIVELY CORRELATED WITH | Anaphylaxis |
| Smooth Muscle Contraction | POSITIVELY CORRELATED WITH | Anaphylaxis |
Reference: