Path ID: DB00661_MESH_D006973_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D014700 | verapamil | Drug |
| InterPro:IPR005446 | Voltage-dependent calcium channel, L-type, alpha-1 subunit | GeneFamily |
| GO:0060402 | calcium ion transport into cytosol | BiologicalProcess |
| GO:0042310 | vasoconstriction | BiologicalProcess |
| HP:0033533 | Increased cardiac output | PhenotypicFeature |
| HP:0032263 | Increased blood pressure | PhenotypicFeature |
| MESH:D006973 | Hypertensive disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Verapamil | DECREASES ACTIVITY OF | Voltage-Dependent Calcium Channel, L-Type, Alpha-1 Subunit |
| Voltage-Dependent Calcium Channel, L-Type, Alpha-1 Subunit | POSITIVELY REGULATES | Calcium Ion Transport Into Cytosol |
| Calcium Ion Transport Into Cytosol | POSITIVELY CORRELATED WITH | Vasoconstriction |
| Vasoconstriction | POSITIVELY CORRELATED WITH | Increased Cardiac Output |
| Increased Cardiac Output | POSITIVELY CORRELATED WITH | Increased Blood Pressure |
| Increased Blood Pressure | MANIFESTATION OF | Hypertensive Disorder |
Reference: