Path ID: DB00661_MESH_D001281_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D014700 | verapamil | Drug |
| InterPro:IPR005446 | Voltage-dependent calcium channel, L-type, alpha-1 subunit | GeneFamily |
| GO:0061337 | cardiac conduction | BiologicalProcess |
| GO:0060047 | heart contraction | BiologicalProcess |
| HP:0001692 | Atrial arrhythmia | PhenotypicFeature |
| MESH:D001281 | Atrial fibrillation | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Verapamil | DECREASES ACTIVITY OF | Voltage-Dependent Calcium Channel, L-Type, Alpha-1 Subunit |
| Voltage-Dependent Calcium Channel, L-Type, Alpha-1 Subunit | POSITIVELY REGULATES | Cardiac Conduction |
| Cardiac Conduction | POSITIVELY CORRELATED WITH | Heart Contraction |
| Heart Contraction | POSITIVELY CORRELATED WITH | Atrial Arrhythmia |
| Atrial Arrhythmia | MANIFESTATION OF | Atrial Fibrillation |
Reference:
- https://go.drugbank.com/drugs/DB00661#mechanism-of-action
- https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL6966/
- https://en.wikipedia.org/wiki/Verapamil#Mechanism_of_action
- https://en.wikipedia.org/wiki/Antiarrhythmic_agent#Class_IV_agents
- https://en.wikipedia.org/wiki/Atrial_fibrillation#Rate_control