Path ID: DB00661_MESH_D000788_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D014700 | verapamil | Drug |
| InterPro:IPR005446 | Voltage-dependent calcium channel, L-type, alpha-1 subunit | GeneFamily |
| GO:0060402 | calcium ion transport into cytosol | BiologicalProcess |
| GO:0042310 | vasoconstriction | BiologicalProcess |
| HP:0033401 | Tissue ischemia | PhenotypicFeature |
| MESH:D000788 | Angina Pectoris, Variant | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Verapamil | DECREASES ACTIVITY OF | Voltage-Dependent Calcium Channel, L-Type, Alpha-1 Subunit |
| Voltage-Dependent Calcium Channel, L-Type, Alpha-1 Subunit | POSITIVELY REGULATES | Calcium Ion Transport Into Cytosol |
| Calcium Ion Transport Into Cytosol | POSITIVELY CORRELATED WITH | Vasoconstriction |
| Vasoconstriction | POSITIVELY CORRELATED WITH | Tissue Ischemia |
| Tissue Ischemia | POSITIVELY CORRELATED WITH | Angina Pectoris, Variant |
Comment: The disease is also known as as Prinzmetal angina.
Reference:
- https://go.drugbank.com/drugs/DB00661#mechanism-of-action
- https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL6966/
- https://en.wikipedia.org/wiki/Verapamil#Mechanism_of_action
- https://en.wikipedia.org/wiki/Antiarrhythmic_agent#Class_IV_agents
- https://en.wikipedia.org/wiki/Variant_angina#Maintenance