Path ID: DB00661_MESH_D000787_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D014700 | verapamil | Drug |
| InterPro:IPR005446 | Voltage-dependent calcium channel, L-type, alpha-1 subunit | GeneFamily |
| GO:0060402 | calcium ion transport into cytosol | BiologicalProcess |
| GO:0042310 | vasoconstriction | BiologicalProcess |
| HP:0033401 | Tissue ischemia | PhenotypicFeature |
| MESH:D000787 | Angina pectoris | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Verapamil | DECREASES ACTIVITY OF | Voltage-Dependent Calcium Channel, L-Type, Alpha-1 Subunit |
| Voltage-Dependent Calcium Channel, L-Type, Alpha-1 Subunit | POSITIVELY REGULATES | Calcium Ion Transport Into Cytosol |
| Calcium Ion Transport Into Cytosol | POSITIVELY CORRELATED WITH | Vasoconstriction |
| Vasoconstriction | POSITIVELY CORRELATED WITH | Tissue Ischemia |
| Tissue Ischemia | POSITIVELY CORRELATED WITH | Angina Pectoris |
Reference: