Path ID: DB00656_MESH_D003865_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D014196 | trazodone | Drug |
| UniProt:P31645 | Sodium-dependent serotonin transporter | Protein |
| InterPro:IPR002231 | 5-hydroxytryptamine receptor family | GeneFamily |
| GO:0051610 | serotonin uptake | BiologicalProcess |
| MESH:D012701 | Serotonin | ChemicalSubstance |
| GO:0060096 | serotonin secretion, neurotransmission | BiologicalProcess |
| MESH:D003865 | Depressive Disorder, Major | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Trazodone | DECREASES ACTIVITY OF | Sodium-Dependent Serotonin Transporter |
| Trazodone | DECREASES ACTIVITY OF | 5-Hydroxytryptamine Receptor Family |
| Sodium-Dependent Serotonin Transporter | PARTICIPATES IN | Serotonin Uptake |
| 5-Hydroxytryptamine Receptor Family | PARTICIPATES IN | Serotonin Uptake |
| Serotonin Uptake | DECREASES ABUNDANCE OF | Serotonin |
| Serotonin | POSITIVELY CORRELATED WITH | Serotonin Secretion, Neurotransmission |
| Serotonin Secretion, Neurotransmission | NEGATIVELY REGULATES | Depressive Disorder, Major |
Reference: