Path ID: DB00641_MESH_D052456_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D019821 | Simvastatin | Drug |
| CHEBI:169041 | simvastatin hydroxy acid | ChemicalSubstance |
| UniProt:P02647 | Apolipoprotein A-I | Protein |
| GO:0034380 | high-density lipoprotein particle assembly | BiologicalProcess |
| MESH:D008076 | Cholesterol, HDL | ChemicalSubstance |
| MESH:D052456 | Hypoalphalipoproteinemias | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Simvastatin | HAS METABOLITE | Simvastatin Hydroxy Acid |
| Simvastatin Hydroxy Acid | INCREASES ACTIVITY OF | Apolipoprotein A-I |
| Apolipoprotein A-I | POSITIVELY REGULATES | High-Density Lipoprotein Particle Assembly |
| High-Density Lipoprotein Particle Assembly | INCREASES ABUNDANCE OF | Cholesterol, Hdl |
| Cholesterol, Hdl | NEGATIVELY CORRELATED WITH | Hypoalphalipoproteinemias |
Comment: Simvastatin is a prodrug in which the 6-membered lactone ring of simvastatin is hydrolyzed to generate the simvastatin hydroxy acid (beta,delta-dihydroxy acid), an active metabolite in the body.
Reference: