Path ID: DB00641_MESH_D020521_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D019821 | Simvastatin | Drug |
| CHEBI:169041 | simvastatin hydroxy acid | ChemicalSubstance |
| UniProt:P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Protein |
| GO:0006695 | cholesterol biosynthetic process | BiologicalProcess |
| MESH:D002784 | Cholesterol | ChemicalSubstance |
| HP:0002621 | Atherosclerosis | PhenotypicFeature |
| MESH:D020521 | Stroke | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Simvastatin | HAS METABOLITE | Simvastatin Hydroxy Acid |
| Simvastatin Hydroxy Acid | DECREASES ACTIVITY OF | 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase |
| 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase | POSITIVELY REGULATES | Cholesterol Biosynthetic Process |
| Cholesterol Biosynthetic Process | INCREASES ABUNDANCE OF | Cholesterol |
| Cholesterol | POSITIVELY CORRELATED WITH | Atherosclerosis |
| Atherosclerosis | POSITIVELY CORRELATED WITH | Stroke |
Comment: Simvastatin is a prodrug in which the 6-membered lactone ring of simvastatin is hydrolyzed to generate the simvastatin hydroxy acid (beta,delta-dihydroxy acid), an active metabolite in the body.
Reference: