Path ID: DB00641_MESH_D015228_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D019821 | Simvastatin | Drug |
| CHEBI:169041 | simvastatin hydroxy acid | ChemicalSubstance |
| UniProt:P06858 | Lipoprotein lipase | Protein |
| GO:0019433 | triglyceride catabolic process | BiologicalProcess |
| MESH:D014280 | Triglycerides | ChemicalSubstance |
| MESH:D015228 | Hypertriglyceridemia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Simvastatin | HAS METABOLITE | Simvastatin Hydroxy Acid |
| Simvastatin Hydroxy Acid | INCREASES ACTIVITY OF | Lipoprotein Lipase |
| Lipoprotein Lipase | POSITIVELY REGULATES | Triglyceride Catabolic Process |
| Triglyceride Catabolic Process | DECREASES ABUNDANCE OF | Triglycerides |
| Triglycerides | POSITIVELY CORRELATED WITH | Hypertriglyceridemia |
Comment: Simvastatin is a prodrug in which the 6-membered lactone ring of simvastatin is hydrolyzed to generate the simvastatin hydroxy acid (beta,delta-dihydroxy acid), an active metabolite in the body.
Reference: