Path ID: DB00641_MESH_D006952_1

db00641-mesh-d006952-1

Concepts

Identifier Name Type
MESH:D019821 Simvastatin Drug
CHEBI:169041 simvastatin hydroxy acid ChemicalSubstance
UniProt:P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Protein
UniProt:P02647 Apolipoprotein A-I Protein
GO:0006695 cholesterol biosynthetic process BiologicalProcess
UniProt:P06858 Lipoprotein lipase Protein
GO:0019433 triglyceride catabolic process BiologicalProcess
GO:0034380 high-density lipoprotein particle assembly BiologicalProcess
MESH:D002784 Cholesterol ChemicalSubstance
MESH:D014280 Triglycerides ChemicalSubstance
MESH:D008076 Cholesterol, HDL ChemicalSubstance
MESH:D006952 Hyperlipoproteinemia Type III Disease

Relationships

NOTE: predicates are annotated in Biolink Model (v1.3.0)

Subject Predicate Object
Simvastatin HAS METABOLITE Simvastatin Hydroxy Acid
Simvastatin Hydroxy Acid DECREASES ACTIVITY OF 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase
Simvastatin Hydroxy Acid INCREASES ACTIVITY OF Lipoprotein Lipase
Simvastatin Hydroxy Acid INCREASES ACTIVITY OF Apolipoprotein A-I
3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase POSITIVELY REGULATES Cholesterol Biosynthetic Process
Lipoprotein Lipase POSITIVELY REGULATES Triglyceride Catabolic Process
Apolipoprotein A-I POSITIVELY REGULATES High-Density Lipoprotein Particle Assembly
Cholesterol Biosynthetic Process INCREASES ABUNDANCE OF Cholesterol
Triglyceride Catabolic Process DECREASES ABUNDANCE OF Triglycerides
High-Density Lipoprotein Particle Assembly INCREASES ABUNDANCE OF Cholesterol, Hdl
Cholesterol POSITIVELY CORRELATED WITH Hyperlipoproteinemia Type Iii
Triglycerides POSITIVELY CORRELATED WITH Hyperlipoproteinemia Type Iii
Cholesterol, Hdl NEGATIVELY CORRELATED WITH Hyperlipoproteinemia Type Iii

Comment: Simvastatin is a prodrug in which the 6-membered lactone ring of simvastatin is hydrolyzed to generate the simvastatin hydroxy acid (beta,delta-dihydroxy acid), an active metabolite in the body.

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