Path ID: DB00641_MESH_D006950_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D019821 | Simvastatin | Drug |
| CHEBI:169041 | simvastatin hydroxy acid | ChemicalSubstance |
| UniProt:P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Protein |
| GO:0006695 | cholesterol biosynthetic process | BiologicalProcess |
| UniProt:P06858 | Lipoprotein lipase | Protein |
| GO:0019433 | triglyceride catabolic process | BiologicalProcess |
| MESH:D002784 | Cholesterol | ChemicalSubstance |
| MESH:D014280 | Triglycerides | ChemicalSubstance |
| MESH:D006950 | Hyperlipidemia, Familial Combined | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Simvastatin | HAS METABOLITE | Simvastatin Hydroxy Acid |
| Simvastatin Hydroxy Acid | DECREASES ACTIVITY OF | 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase |
| Simvastatin Hydroxy Acid | INCREASES ACTIVITY OF | Lipoprotein Lipase |
| 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase | POSITIVELY REGULATES | Cholesterol Biosynthetic Process |
| Lipoprotein Lipase | POSITIVELY REGULATES | Triglyceride Catabolic Process |
| Cholesterol Biosynthetic Process | INCREASES ABUNDANCE OF | Cholesterol |
| Triglyceride Catabolic Process | DECREASES ABUNDANCE OF | Triglycerides |
| Cholesterol | POSITIVELY CORRELATED WITH | Hyperlipidemia, Familial Combined |
| Triglycerides | POSITIVELY CORRELATED WITH | Hyperlipidemia, Familial Combined |
Comment: Simvastatin is a prodrug in which the 6-membered lactone ring of simvastatin is hydrolyzed to generate the simvastatin hydroxy acid (beta,delta-dihydroxy acid), an active metabolite in the body.
Reference:
- https://go.drugbank.com/drugs/DB00641#mechanism-of-action
- https://en.wikipedia.org/wiki/Simvastatin#Pharmacology
- https://www.uniprot.org/uniprot/P04035#function
- https://www.uniprot.org/uniprot/P06858#function
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1760655/
- https://en.wikipedia.org/wiki/Combined_hyperlipidemia