Path ID: DB00635_MESH_D003877_1

db00635-mesh-d003877-1

Concepts

Identifier Name Type
MESH:D011241 prednisone Drug
MESH:D011239 Prednisolone ChemicalSubstance
UniProt:P04150 Glucocorticoid receptor Protein
UniProt:P04083 Annexin A1 Protein
UniProt:P47712 Cytosolic phospholipase A2 Protein
UniProt:P23219 Prostaglandin G/H synthase 1 Protein
UniProt:P35354 Prostaglandin G/H synthase 2 Protein
GO:0019370 leukotriene biosynthetic process BiologicalProcess
GO:0001516 prostaglandin biosynthetic process BiologicalProcess
GO:0006954 inflammatory response BiologicalProcess
HP:0011123 Inflammatory abnormality of the skin PhenotypicFeature
MESH:D003877 Dermatitis, Contact Disease

Relationships

NOTE: predicates are annotated in Biolink Model (v1.3.0)

Subject Predicate Object
Prednisone HAS METABOLITE Prednisolone
Prednisolone INCREASES ACTIVITY OF Glucocorticoid Receptor
Glucocorticoid Receptor INCREASES ACTIVITY OF Annexin A1
Glucocorticoid Receptor DECREASES ACTIVITY OF Prostaglandin G/H Synthase 1
Glucocorticoid Receptor DECREASES ACTIVITY OF Prostaglandin G/H Synthase 2
Annexin A1 DECREASES ACTIVITY OF Cytosolic Phospholipase A2
Prostaglandin G/H Synthase 1 POSITIVELY REGULATES Prostaglandin Biosynthetic Process
Prostaglandin G/H Synthase 2 POSITIVELY REGULATES Prostaglandin Biosynthetic Process
Cytosolic Phospholipase A2 POSITIVELY REGULATES Leukotriene Biosynthetic Process
Cytosolic Phospholipase A2 POSITIVELY REGULATES Prostaglandin Biosynthetic Process
Leukotriene Biosynthetic Process POSITIVELY CORRELATED WITH Inflammatory Response
Prostaglandin Biosynthetic Process POSITIVELY CORRELATED WITH Inflammatory Response
Inflammatory Response POSITIVELY CORRELATED WITH Inflammatory Abnormality Of The Skin
Inflammatory Abnormality Of The Skin CONTRIBUTES TO Dermatitis, Contact

Comment: Prednisone is a synthetic glucocorticoid derived from cortisone. It acts as a prodrug and converted into the active metabolite prednisolone in the liver.

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