Path ID: DB00627_MESH_D015228_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D009525 | Niacin | Drug |
| UniProt:O75907 | Diacylglycerol O-acyltransferase 1 | Protein |
| UniProt:P06858 | Lipoprotein lipase | Protein |
| UniProt:P04114 | Apolipoprotein B-100 | Protein |
| GO:0019432 | triglyceride biosynthetic process | BiologicalProcess |
| GO:0019433 | triglyceride catabolic process | BiologicalProcess |
| MESH:D014280 | Triglycerides | ChemicalSubstance |
| MESH:D015228 | Hypertriglyceridemia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Niacin | DECREASES ACTIVITY OF | Diacylglycerol O-Acyltransferase 1 |
| Niacin | DECREASES ACTIVITY OF | Apolipoprotein B-100 |
| Niacin | INCREASES ACTIVITY OF | Lipoprotein Lipase |
| Diacylglycerol O-Acyltransferase 1 | POSITIVELY REGULATES | Triglyceride Biosynthetic Process |
| Apolipoprotein B-100 | POSITIVELY REGULATES | Triglyceride Biosynthetic Process |
| Lipoprotein Lipase | POSITIVELY REGULATES | Triglyceride Catabolic Process |
| Triglyceride Biosynthetic Process | INCREASES ABUNDANCE OF | Triglycerides |
| Triglyceride Catabolic Process | DECREASES ABUNDANCE OF | Triglycerides |
| Triglycerides | POSITIVELY CORRELATED WITH | Hypertriglyceridemia |
Reference: