Path ID: DB00627_MESH_D006949_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D009525 | Niacin | Drug |
| UniProt:O75907 | Diacylglycerol O-acyltransferase 1 | Protein |
| UniProt:P02647 | Apolipoprotein A-I | Protein |
| UniProt:P04114 | Apolipoprotein B-100 | Protein |
| GO:0019432 | triglyceride biosynthetic process | BiologicalProcess |
| GO:0034380 | high-density lipoprotein particle assembly | BiologicalProcess |
| MESH:D014280 | Triglycerides | ChemicalSubstance |
| MESH:D008075 | Lipoproteins, HDL | ChemicalSubstance |
| MESH:D006949 | Hyperlipidemias | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Niacin | DECREASES ACTIVITY OF | Diacylglycerol O-Acyltransferase 1 |
| Niacin | DECREASES ACTIVITY OF | Apolipoprotein B-100 |
| Niacin | INCREASES ACTIVITY OF | Apolipoprotein A-I |
| Diacylglycerol O-Acyltransferase 1 | POSITIVELY REGULATES | Triglyceride Biosynthetic Process |
| Apolipoprotein B-100 | POSITIVELY REGULATES | Triglyceride Biosynthetic Process |
| Apolipoprotein A-I | POSITIVELY REGULATES | High-Density Lipoprotein Particle Assembly |
| Triglyceride Biosynthetic Process | INCREASES ABUNDANCE OF | Triglycerides |
| High-Density Lipoprotein Particle Assembly | INCREASES ABUNDANCE OF | Lipoproteins, Hdl |
| Triglycerides | POSITIVELY CORRELATED WITH | Hyperlipidemias |
| Lipoproteins, Hdl | NEGATIVELY CORRELATED WITH | Hyperlipidemias |
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