Path ID: DB00627_MESH_D006937_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D009525 | Niacin | Drug |
| UniProt:P11597 | Cholesteryl ester transfer protein | Protein |
| UniProt:P02647 | Apolipoprotein A-I | Protein |
| GO:0034379 | very-low-density lipoprotein particle assembly | BiologicalProcess |
| GO:0034380 | high-density lipoprotein particle assembly | BiologicalProcess |
| MESH:D008079 | Lipoproteins, VLDL | ChemicalSubstance |
| MESH:D008075 | Lipoproteins, HDL | ChemicalSubstance |
| MESH:D006937 | Hypercholesterolemia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Niacin | DECREASES ACTIVITY OF | Cholesteryl Ester Transfer Protein |
| Niacin | INCREASES ACTIVITY OF | Apolipoprotein A-I |
| Cholesteryl Ester Transfer Protein | POSITIVELY REGULATES | Very-Low-Density Lipoprotein Particle Assembly |
| Apolipoprotein A-I | POSITIVELY REGULATES | High-Density Lipoprotein Particle Assembly |
| Very-Low-Density Lipoprotein Particle Assembly | INCREASES ABUNDANCE OF | Lipoproteins, Vldl |
| High-Density Lipoprotein Particle Assembly | INCREASES ABUNDANCE OF | Lipoproteins, Hdl |
| Lipoproteins, Vldl | POSITIVELY CORRELATED WITH | Hypercholesterolemia |
| Lipoproteins, Hdl | NEGATIVELY CORRELATED WITH | Hypercholesterolemia |
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