Path ID: DB00622_MESH_D006973_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D009529 | Nicardipine | Drug |
| UniProt:Q13936 | Voltage-dependent L-type calcium channel subunit alpha-1C | Protein |
| UniProt:Q08289 | Voltage-dependent L-type calcium channel subunit beta-2 | Protein |
| UniProt:P54289 | Voltage-dependent calcium channel subunit alpha-2/delta-1 | Protein |
| UniProt:Q01668 | Voltage-dependent L-type calcium channel subunit alpha-1D | Protein |
| GO:0070509 | Transmembrane calcium influx | BiologicalProcess |
| GO:0045907 | Positive regulation of vasoconstriction | BiologicalProcess |
| HP:0032263 | Increased blood pressure | PhenotypicFeature |
| MESH:D006973 | Hypertensive disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Nicardipine | DECREASES ACTIVITY OF | Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1C |
| Nicardipine | DECREASES ACTIVITY OF | Voltage-Dependent L-Type Calcium Channel Subunit Beta-2 |
| Nicardipine | DECREASES ACTIVITY OF | Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-1 |
| Nicardipine | DECREASES ACTIVITY OF | Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1D |
| Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1C | PARTICIPATES IN | Transmembrane Calcium Influx |
| Voltage-Dependent L-Type Calcium Channel Subunit Beta-2 | PARTICIPATES IN | Transmembrane Calcium Influx |
| Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-1 | PARTICIPATES IN | Transmembrane Calcium Influx |
| Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1D | PARTICIPATES IN | Transmembrane Calcium Influx |
| Transmembrane Calcium Influx | CONTRIBUTES TO | Positive Regulation Of Vasoconstriction |
| Positive Regulation Of Vasoconstriction | POSITIVELY CORRELATED WITH | Increased Blood Pressure |
| Increased Blood Pressure | POSITIVELY CORRELATED WITH | Hypertensive Disorder |
Reference: