Path ID: DB00619_MESH_D046152_1

db00619-mesh-d046152-1

Concepts

Identifier Name Type
MESH:D000068877 imatinib Drug
UniProt:P10721 Mast/stem cell growth factor receptor Kit Protein
UniProt:P16234 Platelet-derived growth factor receptor alpha Protein
GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway BiologicalProcess
GO:0038109 Kit signaling pathway BiologicalProcess
GO:0030154 cell differentiation BiologicalProcess
GO:0008283 cell population proliferation BiologicalProcess
MESH:D002470 Cell Survival BiologicalProcess
MESH:D046152 Gastrointestinal stromal tumor Disease

Relationships

NOTE: predicates are annotated in Biolink Model (v1.3.0)

Subject Predicate Object
Imatinib DECREASES ACTIVITY OF Mast/Stem Cell Growth Factor Receptor Kit
Imatinib DECREASES ACTIVITY OF Platelet-Derived Growth Factor Receptor Alpha
Platelet-Derived Growth Factor Receptor Alpha POSITIVELY REGULATES Platelet-Derived Growth Factor Receptor-Alpha Signaling Pathway
Platelet-Derived Growth Factor Receptor-Alpha Signaling Pathway POSITIVELY CORRELATED WITH Cell Population Proliferation
Platelet-Derived Growth Factor Receptor-Alpha Signaling Pathway POSITIVELY CORRELATED WITH Cell Survival
Mast/Stem Cell Growth Factor Receptor Kit POSITIVELY REGULATES Kit Signaling Pathway
Kit Signaling Pathway POSITIVELY CORRELATED WITH Cell Population Proliferation
Kit Signaling Pathway POSITIVELY CORRELATED WITH Cell Survival
Kit Signaling Pathway POSITIVELY CORRELATED WITH Cell Differentiation
Cell Population Proliferation POSITIVELY CORRELATED WITH Gastrointestinal Stromal Tumor
Cell Survival POSITIVELY CORRELATED WITH Gastrointestinal Stromal Tumor
Cell Differentiation POSITIVELY CORRELATED WITH Gastrointestinal Stromal Tumor

Comment: The majority of Gastrointestinal stromal tumor patients have mutations on the KIT or PDGFRA genes (95% of all patients).

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