Path ID: DB00619_MESH_D034721_2
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D000068877 | imatinib | Drug |
| UniProt:P10721 | Mast/stem cell growth factor receptor Kit | Protein |
| GO:0038109 | Kit signaling pathway | BiologicalProcess |
| GO:0030154 | cell differentiation | BiologicalProcess |
| GO:0008283 | cell population proliferation | BiologicalProcess |
| MESH:D002470 | Cell Survival | BiologicalProcess |
| MESH:D008407 | Mast Cells | Cell |
| MESH:D034721 | Mastocytosis, Systemic | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Imatinib | DECREASES ACTIVITY OF | Mast/Stem Cell Growth Factor Receptor Kit |
| Mast/Stem Cell Growth Factor Receptor Kit | POSITIVELY REGULATES | Kit Signaling Pathway |
| Kit Signaling Pathway | POSITIVELY CORRELATED WITH | Cell Population Proliferation |
| Kit Signaling Pathway | POSITIVELY CORRELATED WITH | Cell Survival |
| Kit Signaling Pathway | POSITIVELY CORRELATED WITH | Cell Differentiation |
| Cell Population Proliferation | INCREASES ABUNDANCE OF | Mast Cells |
| Mast Cells | CORRELATED WITH | Mastocytosis, Systemic |
| Cell Survival | POSITIVELY CORRELATED WITH | Mastocytosis, Systemic |
| Cell Differentiation | POSITIVELY CORRELATED WITH | Mastocytosis, Systemic |
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