Path ID: DB00619_MESH_D018223_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D000068877 | imatinib | Drug |
| UniProt:P16234 | Platelet-derived growth factor receptor alpha | Protein |
| GO:0030154 | cell differentiation | BiologicalProcess |
| GO:0008283 | cell population proliferation | BiologicalProcess |
| MESH:D002470 | Cell Survival | BiologicalProcess |
| MESH:D018223 | Dermatofibrosarcoma | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Imatinib | DECREASES ACTIVITY OF | Platelet-Derived Growth Factor Receptor Alpha |
| Platelet-Derived Growth Factor Receptor Alpha | POSITIVELY REGULATES | Cell Differentiation |
| Platelet-Derived Growth Factor Receptor Alpha | POSITIVELY REGULATES | Cell Population Proliferation |
| Platelet-Derived Growth Factor Receptor Alpha | POSITIVELY REGULATES | Cell Survival |
| Cell Population Proliferation | POSITIVELY CORRELATED WITH | Dermatofibrosarcoma |
| Cell Survival | POSITIVELY CORRELATED WITH | Dermatofibrosarcoma |
| Cell Differentiation | POSITIVELY CORRELATED WITH | Dermatofibrosarcoma |
Comment: The majority of dermatofibrosarcoma tumours have two genes fused due to a translocation involving the collagen gene (COL1A1) and the platelet-derived growth factor (PDGF). The latter can be further subdivided giving rise to PDGFA, for example, which is an oncogene.
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