Path ID: DB00617_MESH_D004832_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C005731 | Paramethadione | Drug |
| UniProt:O43497 | Voltage-dependent T-type calcium channel subunit alpha-1G | Protein |
| UniProt:Q9P0X4 | Voltage-dependent T-type calcium channel subunit alpha-1I | Protein |
| UniProt:O95180 | Voltage-dependent T-type calcium channel subunit alpha-1H | Protein |
| GO:0005245 | Voltage-gated calcium channel activity | MolecularActivity |
| GO:0019228 | Neuronal action potential | BiologicalProcess |
| GO:0023041 | Neuronal signal transduction | BiologicalProcess |
| MESH:D004832 | Absence seizure | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Paramethadione | DECREASES ACTIVITY OF | Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1G |
| Paramethadione | DECREASES ACTIVITY OF | Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1H |
| Paramethadione | DECREASES ACTIVITY OF | Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1I |
| Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1G | POSITIVELY REGULATES | Voltage-Gated Calcium Channel Activity |
| Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1H | POSITIVELY REGULATES | Voltage-Gated Calcium Channel Activity |
| Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1I | POSITIVELY REGULATES | Voltage-Gated Calcium Channel Activity |
| Voltage-Gated Calcium Channel Activity | POSITIVELY REGULATES | Neuronal Action Potential |
| Neuronal Action Potential | POSITIVELY REGULATES | Neuronal Signal Transduction |
| Neuronal Signal Transduction | POSITIVELY CORRELATED WITH | Absence Seizure |
Reference: