Path ID: DB00612_MESH_D006973_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D017298 | bisoprolol | Drug |
| UniProt:P08588 | Beta-1 adrenergic receptor | Protein |
| UBERON:0034729 | sympathetic nerve | GrossAnatomicalStructure |
| GO:0002001 | renin secretion into blood stream | BiologicalProcess |
| GO:0042310 | vasoconstriction | BiologicalProcess |
| HP:0033533 | Increased cardiac output | PhenotypicFeature |
| HP:0032263 | Increased blood pressure | PhenotypicFeature |
| MESH:D006973 | Hypertensive disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Bisoprolol | DECREASES ACTIVITY OF | Sympathetic Nerve |
| Sympathetic Nerve | POSITIVELY CORRELATED WITH | Vasoconstriction |
| Bisoprolol | DECREASES ACTIVITY OF | Beta-1 Adrenergic Receptor |
| Beta-1 Adrenergic Receptor | POSITIVELY CORRELATED WITH | Increased Cardiac Output |
| Increased Cardiac Output | POSITIVELY CORRELATED WITH | Increased Blood Pressure |
| Bisoprolol | NEGATIVELY CORRELATED WITH | Renin Secretion Into Blood Stream |
| Renin Secretion Into Blood Stream | POSITIVELY CORRELATED WITH | Vasoconstriction |
| Vasoconstriction | POSITIVELY CORRELATED WITH | Increased Blood Pressure |
| Increased Blood Pressure | POSITIVELY CORRELATED WITH | Hypertensive Disorder |
Comment: At higher doses, bisoprolol antagonizes the B2 receptors, but is mainly selective for B1 receptors.
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