Path ID: DB00604_MESH_D005764_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D020117 | cisapride | Drug |
| UniProt:Q13639 | 5-hydroxytryptamine receptor 4 | Protein |
| UniProt:P46098 | 5-hydroxytryptamine receptor 3A | Protein |
| UniProt:P28223 | 5-hydroxytryptamine receptor 2A | Protein |
| GO:0014055 | Acetylcholine secretion, neurotransmission | BiologicalProcess |
| UBERON:0002439 | myenteric nerve plexus | GrossAnatomicalStructure |
| UBERON:0001202 | pyloric sphincter | GrossAnatomicalStructure |
| GO:0035482 | Gastric motility | BiologicalProcess |
| GO:0035483 | Gastric emptying | BiologicalProcess |
| MESH:D005764 | Gastroesophageal reflux disease | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Cisapride | INCREASES ACTIVITY OF | 5-Hydroxytryptamine Receptor 4 |
| Cisapride | INCREASES ACTIVITY OF | 5-Hydroxytryptamine Receptor 3A |
| Cisapride | INCREASES ACTIVITY OF | 5-Hydroxytryptamine Receptor 2A |
| 5-Hydroxytryptamine Receptor 4 | POSITIVELY REGULATES | Acetylcholine Secretion, Neurotransmission |
| 5-Hydroxytryptamine Receptor 3A | POSITIVELY REGULATES | Acetylcholine Secretion, Neurotransmission |
| 5-Hydroxytryptamine Receptor 2A | POSITIVELY REGULATES | Acetylcholine Secretion, Neurotransmission |
| Acetylcholine Secretion, Neurotransmission | POSITIVELY REGULATES | Myenteric Nerve Plexus |
| Acetylcholine Secretion, Neurotransmission | POSITIVELY REGULATES | Pyloric Sphincter |
| Myenteric Nerve Plexus | NEGATIVELY REGULATES | Gastroesophageal Reflux Disease |
| Pyloric Sphincter | NEGATIVELY REGULATES | Gastroesophageal Reflux Disease |
| Acetylcholine Secretion, Neurotransmission | POSITIVELY REGULATES | Gastric Motility |
| Gastric Motility | POSITIVELY REGULATES | Gastric Emptying |
| Gastric Emptying | NEGATIVELY REGULATES | Gastroesophageal Reflux Disease |
Reference: