Path ID: DB00602_MESH_D009855_2
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D007559 | ivermectin | Drug |
| InterPro:IPR015680 | Glutamate-Gated Chloride Channel | GeneFamily |
| GO:0005254 | chloride channel activity | MolecularActivity |
| GO:0060081 | membrane hyperpolarization | BiologicalProcess |
| GO:0099565 | chemical synaptic transmission, postsynaptic | BiologicalProcess |
| taxonomy:6282 | Onchocerca volvulus | OrganismTaxon |
| MESH:D009855 | Onchocerciasis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Ivermectin | INCREASES ACTIVITY OF | Glutamate-Gated Chloride Channel |
| Glutamate-Gated Chloride Channel | POSITIVELY REGULATES | Chloride Channel Activity |
| Chloride Channel Activity | POSITIVELY CORRELATED WITH | Membrane Hyperpolarization |
| Membrane Hyperpolarization | NEGATIVELY REGULATES | Chemical Synaptic Transmission, Postsynaptic |
| Chemical Synaptic Transmission, Postsynaptic | IN TAXON | Onchocerca Volvulus |
| Onchocerca Volvulus | CAUSES | Onchocerciasis |
Comment: Disease is also known as Infection by Onchocerca volvulus as per the original file.
Reference: