Path ID: DB00602_MESH_D009855_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D007559 | ivermectin | Drug |
| InterPro:IPR015680 | glutimate-gated chloride channels | GeneFamily |
| CHEBI:17996 | chloride ion | ChemicalSubstance |
| GO:0060081 | membrane hyperpolarization | BiologicalProcess |
| MESH:D010243 | Paralysis | BiologicalProcess |
| taxonomy:6282 | Onchocerca volvulus | OrganismTaxon |
| MESH:D009855 | Onchocerciasis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Ivermectin | INCREASES ACTIVITY OF | Glutimate-Gated Chloride Channels |
| Glutimate-Gated Chloride Channels | INCREASES ABUNDANCE OF | Chloride Ion |
| Chloride Ion | PARTICIPATES IN | Membrane Hyperpolarization |
| Membrane Hyperpolarization | PRECEDES | Paralysis |
| Paralysis | NEGATIVELY REGULATES | Onchocerca Volvulus |
| Onchocerca Volvulus | CAUSES | Onchocerciasis |
Reference: