Path ID: DB00594_MESH_D006973_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D000584 | amiloride | Drug |
| UniProt:P51170 | Amiloride-sensitive sodium channel subunit gamma | Protein |
| UniProt:P37088 | Amiloride-sensitive sodium channel subunit alpha | Protein |
| UniProt:P51168 | Amiloride-sensitive sodium channel subunit beta | Protein |
| GO:0070294 | renal sodium ion absorption | BiologicalProcess |
| GO:0003092 | renal water retention | BiologicalProcess |
| HP:0032263 | Increased blood pressure | PhenotypicFeature |
| MESH:D006973 | Hypertensive disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Amiloride | DECREASES ACTIVITY OF | Amiloride-Sensitive Sodium Channel Subunit Gamma |
| Amiloride | DECREASES ACTIVITY OF | Amiloride-Sensitive Sodium Channel Subunit Alpha |
| Amiloride | DECREASES ACTIVITY OF | Amiloride-Sensitive Sodium Channel Subunit Beta |
| Amiloride-Sensitive Sodium Channel Subunit Gamma | PARTICIPATES IN | Renal Sodium Ion Absorption |
| Amiloride-Sensitive Sodium Channel Subunit Alpha | PARTICIPATES IN | Renal Sodium Ion Absorption |
| Amiloride-Sensitive Sodium Channel Subunit Beta | PARTICIPATES IN | Renal Sodium Ion Absorption |
| Renal Sodium Ion Absorption | POSITIVELY CORRELATED WITH | Renal Water Retention |
| Renal Water Retention | POSITIVELY CORRELATED WITH | Increased Blood Pressure |
| Increased Blood Pressure | MANIFESTATION OF | Hypertensive Disorder |
Reference: