Path ID: DB00589_MESH_D008881_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D008090 | Lisuride | Drug |
| UniProt:P28222 | 5-hydroxytryptamine receptor 1B | Protein |
| UniProt:P28221 | 5-hydroxytryptamine receptor 1D | Protein |
| GO:0004993 | G protein-coupled serotonin receptor activity | MolecularActivity |
| GO:0042310 | Vasoconstriction | BiologicalProcess |
| MESH:D008881 | Migraine | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Lisuride | POSITIVELY REGULATES | 5-Hydroxytryptamine Receptor 1B |
| Lisuride | POSITIVELY REGULATES | 5-Hydroxytryptamine Receptor 1D |
| 5-Hydroxytryptamine Receptor 1B | POSITIVELY REGULATES | G Protein-Coupled Serotonin Receptor Activity |
| 5-Hydroxytryptamine Receptor 1D | POSITIVELY REGULATES | G Protein-Coupled Serotonin Receptor Activity |
| G Protein-Coupled Serotonin Receptor Activity | POSITIVELY CORRELATED WITH | Vasoconstriction |
| Vasoconstriction | NEGATIVELY CORRELATED WITH | Migraine |
Comment: Lisuride is used to prevent migraine attacks in low doses. Due to its highly non-selective pharmacological activity, lisuride is described as a “dirty drug”. The exact mechanism of action of lisuride is not clear however it is likely due to agonism of 5-HT1B/1D receptors.
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