Path ID: DB00589_MESH_D000568_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D008090 | Lisuride | Drug |
| UniProt:P14416 | D2 dopamine receptor | Protein |
| GO:0007195 | Adenylate cyclase-inhibiting dopamine receptor signaling pathway | BiologicalProcess |
| CHEBI:17489 | 3’,5’-cyclic AMP | ChemicalSubstance |
| GO:0051209 | Release of sequestered calcium ion into cytosol | BiologicalProcess |
| GO:1902722 | Positive regulation of prolactin secretion | BiologicalProcess |
| MESH:D006966 | Hyperprolactinemia | Disease |
| MESH:D000568 | Amenorrhea | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Lisuride | INCREASES ACTIVITY OF | D2 Dopamine Receptor |
| D2 Dopamine Receptor | PARTICIPATES IN | Adenylate Cyclase-Inhibiting Dopamine Receptor Signaling Pathway |
| Adenylate Cyclase-Inhibiting Dopamine Receptor Signaling Pathway | DECREASES ABUNDANCE OF | 3’,5’-Cyclic Amp |
| 3’,5’-Cyclic Amp | POSITIVELY REGULATES | Release Of Sequestered Calcium Ion Into Cytosol |
| Release Of Sequestered Calcium Ion Into Cytosol | CONTRIBUTES TO | Positive Regulation Of Prolactin Secretion |
| Positive Regulation Of Prolactin Secretion | CAUSES | Hyperprolactinemia |
| Hyperprolactinemia | CAUSES | Amenorrhea |
Comment: Lisuride is used to treat hyperprolactinemic amenorrhea.
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