Path ID: DB00586_MESH_D010003_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| DB:DB00586 | Diclofenac | Drug |
| UniProt:P35354 | Prostaglandin G/H synthase 2 | Protein |
| UniProt:P23219 | Prostaglandin G/H synthase 1 | Protein |
| MESH:D011453 | Prostaglandins | ChemicalSubstance |
| GO:0006954 | Inflammatory response | BiologicalProcess |
| HP:0002829 | Joint pain | PhenotypicFeature |
| HP:0001386 | Joint swelling | PhenotypicFeature |
| MESH:D010003 | Osteoarthritis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Diclofenac | DECREASES ACTIVITY OF | Prostaglandin G/H Synthase 2 |
| Diclofenac | DECREASES ACTIVITY OF | Prostaglandin G/H Synthase 1 |
| Prostaglandin G/H Synthase 2 | INCREASES ABUNDANCE OF | Prostaglandins |
| Prostaglandin G/H Synthase 1 | INCREASES ABUNDANCE OF | Prostaglandins |
| Prostaglandins | PARTICIPATES IN | Inflammatory Response |
| Inflammatory Response | POSITIVELY CORRELATED WITH | Joint Pain |
| Inflammatory Response | POSITIVELY CORRELATED WITH | Joint Swelling |
| Joint Swelling | POSITIVELY CORRELATED WITH | Osteoarthritis |
| Joint Pain | POSITIVELY CORRELATED WITH | Osteoarthritis |
Reference: