Path ID: DB00575_MESH_D006973_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D003000 | Clonidine | Drug |
| UniProt:P08913 | Alpha-2A adrenergic receptor | Protein |
| UniProt:P18089 | Alpha-2B adrenergic receptor | Protein |
| UniProt:P18825 | Alpha-2C adrenergic receptor | Protein |
| GO:0048243 | norepinephrine secretion | BiologicalProcess |
| GO:0042310 | vasoconstriction | BiologicalProcess |
| MESH:D006973 | Hypertension | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Clonidine | INCREASES ACTIVITY OF | Alpha-2A Adrenergic Receptor |
| Clonidine | INCREASES ACTIVITY OF | Alpha-2B Adrenergic Receptor |
| Clonidine | INCREASES ACTIVITY OF | Alpha-2C Adrenergic Receptor |
| Alpha-2A Adrenergic Receptor | NEGATIVELY REGULATES | Norepinephrine Secretion |
| Alpha-2B Adrenergic Receptor | NEGATIVELY REGULATES | Norepinephrine Secretion |
| Alpha-2C Adrenergic Receptor | NEGATIVELY REGULATES | Norepinephrine Secretion |
| Norepinephrine Secretion | PARTICIPATES IN | Vasoconstriction |
| Vasoconstriction | POSITIVELY CORRELATED WITH | Hypertension |
Reference:
- https://go.drugbank.com/drugs/DB00575#mechanism-of-action
- https://en.wikipedia.org/wiki/Clonidine#Pharmacology
- https://www.uniprot.org/uniprot/P08913#function
- https://www.uniprot.org/uniprot/P18089#function
- https://www.uniprot.org/uniprot/P18825#function
- https://en.wikipedia.org/wiki/Alpha-2_adrenergic_receptor
- https://en.wikipedia.org/wiki/Hypertension