Path ID: DB00571_MESH_D002312_1

Concepts
Identifier | Name | Type |
---|---|---|
MESH:D011433 | Propranolol | Drug |
UniProt:P08588 | Beta-1 adrenergic receptor | Protein |
UniProt:P07550 | Beta-2 adrenergic receptor | Protein |
MESH:D004837 | Epinephrine | ChemicalSubstance |
MESH:D009638 | Norepinephrine | ChemicalSubstance |
HP:0000822 | Hypertension | PhenotypicFeature |
HP:0001714 | Ventricular hypertrophy | PhenotypicFeature |
MESH:D002312 | Cardiomyopathy, Hypertrophic | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
Subject | Predicate | Object |
---|---|---|
Propranolol | DECREASES ACTIVITY OF | Beta-1 Adrenergic Receptor |
Propranolol | DECREASES ACTIVITY OF | Beta-2 Adrenergic Receptor |
Beta-1 Adrenergic Receptor | POSITIVELY CORRELATED WITH | Epinephrine |
Beta-1 Adrenergic Receptor | POSITIVELY CORRELATED WITH | Norepinephrine |
Beta-2 Adrenergic Receptor | POSITIVELY CORRELATED WITH | Epinephrine |
Beta-2 Adrenergic Receptor | POSITIVELY CORRELATED WITH | Norepinephrine |
Epinephrine | POSITIVELY CORRELATED WITH | Hypertension |
Norepinephrine | POSITIVELY CORRELATED WITH | Hypertension |
Hypertension | CONTRIBUTES TO | Ventricular Hypertrophy |
Ventricular Hypertrophy | MANIFESTATION OF | Cardiomyopathy, Hypertrophic |
Reference:
- https://go.drugbank.com/drugs/DB00571#mechanism-of-action
- https://en.wikipedia.org/wiki/Propranolol#Pharmacology
- https://www.uniprot.org/uniprot/P08588#function
- https://www.uniprot.org/uniprot/P07550#function
- https://www.sciencedirect.com/science/article/pii/S0735109701014334
- https://en.wikipedia.org/wiki/Hypertrophic_cardiomyopathy