Path ID: DB00571_MESH_D000787_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D011433 | Propranolol | Drug |
| UniProt:P08588 | Beta-1 adrenergic receptor | Protein |
| UniProt:P07550 | Beta-2 adrenergic receptor | Protein |
| GO:0042310 | vasoconstriction | BiologicalProcess |
| HP:0033533 | Increased cardiac output | PhenotypicFeature |
| UniProt:P00797 | Renin | Protein |
| HP:0032263 | Increased blood pressure | PhenotypicFeature |
| HP:0000822 | Hypertension | PhenotypicFeature |
| MESH:D000787 | Angina Pectoris | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Propranolol | DECREASES ACTIVITY OF | Beta-1 Adrenergic Receptor |
| Propranolol | DECREASES ACTIVITY OF | Beta-2 Adrenergic Receptor |
| Beta-2 Adrenergic Receptor | POSITIVELY CORRELATED WITH | Vasoconstriction |
| Beta-1 Adrenergic Receptor | POSITIVELY REGULATES | Increased Cardiac Output |
| Beta-1 Adrenergic Receptor | POSITIVELY REGULATES | Renin |
| Renin | POSITIVELY REGULATES | Vasoconstriction |
| Vasoconstriction | POSITIVELY CORRELATED WITH | Increased Blood Pressure |
| Increased Blood Pressure | CONTRIBUTES TO | Hypertension |
| Increased Cardiac Output | CONTRIBUTES TO | Hypertension |
| Hypertension | POSITIVELY CORRELATED WITH | Angina Pectoris |
Reference: