Path ID: DB00568_MESH_D009325_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D002936 | Cinnarizine | Drug |
| InterPro:IPR005446 | Voltage-dependent calcium channel, L-type, alpha-1 subunit | GeneFamily |
| InterPro:IPR005445 | Voltage-dependent calcium channel, T-type, alpha-1 subunit | GeneFamily |
| UniProt:P35367 | Histamine H1 receptor | Protein |
| GO:0070588 | calcium ion transmembrane transport | BiologicalProcess |
| GO:0014829 | vascular associated smooth muscle contraction | BiologicalProcess |
| UBERON:0002282 | stria vascularis of cochlear duct | GrossAnatomicalStructure |
| MESH:D009325 | Nausea | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Cinnarizine | NEGATIVELY REGULATES | Voltage-Dependent Calcium Channel, L-Type, Alpha-1 Subunit |
| Cinnarizine | NEGATIVELY REGULATES | Voltage-Dependent Calcium Channel, T-Type, Alpha-1 Subunit |
| Cinnarizine | DECREASES ACTIVITY OF | Histamine H1 Receptor |
| Voltage-Dependent Calcium Channel, L-Type, Alpha-1 Subunit | POSITIVELY REGULATES | Calcium Ion Transmembrane Transport |
| Voltage-Dependent Calcium Channel, T-Type, Alpha-1 Subunit | POSITIVELY REGULATES | Calcium Ion Transmembrane Transport |
| Histamine H1 Receptor | POSITIVELY REGULATES | Vascular Associated Smooth Muscle Contraction |
| Calcium Ion Transmembrane Transport | POSITIVELY CORRELATED WITH | Vascular Associated Smooth Muscle Contraction |
| Vascular Associated Smooth Muscle Contraction | OCCURS IN | Stria Vascularis Of Cochlear Duct |
| Stria Vascularis Of Cochlear Duct | CORRELATED WITH | Nausea |
Reference: