Path ID: DB00564_MESH_D014277_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D002220 | carbamazepine | Drug |
| InterPro:IPR001696 | Voltage gated sodium channel, alpha subunit | GeneFamily |
| GO:0051899 | membrane depolarization | BiologicalProcess |
| GO:0019228 | neuronal action potential | BiologicalProcess |
| GO:0050806 | positive regulation of synaptic transmission | BiologicalProcess |
| GO:1904058 | positive regulation of sensory perception of pain | BiologicalProcess |
| MESH:D014277 | Trigeminal neuralgia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Carbamazepine | DECREASES ACTIVITY OF | Voltage Gated Sodium Channel, Alpha Subunit |
| Voltage Gated Sodium Channel, Alpha Subunit | POSITIVELY CORRELATED WITH | Membrane Depolarization |
| Membrane Depolarization | POSITIVELY REGULATES | Neuronal Action Potential |
| Neuronal Action Potential | CONTRIBUTES TO | Positive Regulation Of Synaptic Transmission |
| Positive Regulation Of Synaptic Transmission | ACTIVELY INVOLVED IN | Positive Regulation Of Sensory Perception Of Pain |
| Positive Regulation Of Sensory Perception Of Pain | CAUSES | Trigeminal Neuralgia |
Reference: