Path ID: DB00563_MESH_D008228_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D008727 | methotrexate | Drug |
| UniProt:P04818 | Thymidylate synthase | Protein |
| UniProt:P00374 | Dihydrofolate reductase | Protein |
| GO:0046105 | Thymidine biosynthetic process | BiologicalProcess |
| UniProt:P31939 | Bifunctional purine biosynthesis protein ATIC | Protein |
| GO:0042451 | Purine nucleoside biosynthetic process | BiologicalProcess |
| GO:0071897 | DNA biosynthetic process | BiologicalProcess |
| GO:0032774 | RNA biosynthetic process | BiologicalProcess |
| GO:0008283 | Cell population proliferation | BiologicalProcess |
| CL:0001064 | cancer cell | Cell |
| MESH:D008228 | Non-Hodgkin’s lymphoma | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Methotrexate | DECREASES ACTIVITY OF | Thymidylate Synthase |
| Methotrexate | DECREASES ACTIVITY OF | Dihydrofolate Reductase |
| Thymidylate Synthase | PARTICIPATES IN | Thymidine Biosynthetic Process |
| Dihydrofolate Reductase | PARTICIPATES IN | Thymidine Biosynthetic Process |
| Thymidine Biosynthetic Process | PRECEDES | Dna Biosynthetic Process |
| Methotrexate | DECREASES ACTIVITY OF | Bifunctional Purine Biosynthesis Protein Atic |
| Bifunctional Purine Biosynthesis Protein Atic | PARTICIPATES IN | Purine Nucleoside Biosynthetic Process |
| Purine Nucleoside Biosynthetic Process | PRECEDES | Rna Biosynthetic Process |
| Rna Biosynthetic Process | PART OF | Cell Population Proliferation |
| Dna Biosynthetic Process | PART OF | Cell Population Proliferation |
| Cell Population Proliferation | LOCATED IN | Cancer Cell |
| Cancer Cell | POSITIVELY CORRELATED WITH | Non-Hodgkin’S Lymphoma |
Reference: