Path ID: DB00555_MESH_D065768_1

db00555-mesh-d065768-1

Concepts

Identifier Name Type
MESH:C047781 lamotrigine Drug
InterPro:IPR001696 Voltage gated sodium channel, alpha subunit GeneFamily
GO:0061530 aspartate secretion, neurotransmission BiologicalProcess
GO:0061535 glutamate secretion, neurotransmission BiologicalProcess
HP:0032792 Tonic seizure PhenotypicFeature
MESH:D065768 Lennox-Gastaut syndrome Disease

Relationships

NOTE: predicates are annotated in Biolink Model (v1.3.0)

Subject Predicate Object
Lamotrigine NEGATIVELY REGULATES Voltage Gated Sodium Channel, Alpha Subunit
Voltage Gated Sodium Channel, Alpha Subunit POSITIVELY REGULATES Aspartate Secretion, Neurotransmission
Voltage Gated Sodium Channel, Alpha Subunit POSITIVELY REGULATES Glutamate Secretion, Neurotransmission
Aspartate Secretion, Neurotransmission POSITIVELY CORRELATED WITH Tonic Seizure
Glutamate Secretion, Neurotransmission POSITIVELY CORRELATED WITH Tonic Seizure
Tonic Seizure POSITIVELY CORRELATED WITH Lennox-Gastaut Syndrome

Comment: This drug may also affect GABA-mediated synaptic transmission as listed by DrugBank (https://go.drugbank.com/drugs/DB00555#BE0000013). However, this is contentious and if the drug does modulate GABA it’s not known whether it is as agonist or antagonist due to conflicting data (at best it would be a weak modulation seen in animal models only). Note that the drug could be contraindicated for treatment of seizures as it can exacerbate them, specially the myoclonic type (https://pubmed.ncbi.nlm.nih.gov/9596203/).

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