Path ID: DB00555_MESH_D012640_1

db00555-mesh-d012640-1

Concepts

Identifier Name Type
MESH:C047781 lamotrigine Drug
InterPro:IPR001696 Voltage gated sodium channel, alpha subunit GeneFamily
GO:0061530 aspartate secretion, neurotransmission BiologicalProcess
GO:0061535 glutamate secretion, neurotransmission BiologicalProcess
HP:0020219 Motor seizure PhenotypicFeature
MESH:D012640 Seizures Disease

Relationships

NOTE: predicates are annotated in Biolink Model (v1.3.0)

Subject Predicate Object
Lamotrigine NEGATIVELY REGULATES Voltage Gated Sodium Channel, Alpha Subunit
Voltage Gated Sodium Channel, Alpha Subunit POSITIVELY REGULATES Aspartate Secretion, Neurotransmission
Voltage Gated Sodium Channel, Alpha Subunit POSITIVELY REGULATES Glutamate Secretion, Neurotransmission
Aspartate Secretion, Neurotransmission POSITIVELY CORRELATED WITH Motor Seizure
Glutamate Secretion, Neurotransmission POSITIVELY CORRELATED WITH Motor Seizure
Motor Seizure POSITIVELY CORRELATED WITH Seizures

Comment: This drug may also affect GABA-mediated synaptic transmission (https://go.drugbank.com/drugs/DB00555#BE0000013). However this is rather contentious, so it has not been annotated as such in here. Besides if the drug does modulate gamma-aminobutyric acid receptor it’s a rather weak inhibition seen in animal models (yet to be determined in humans). Note that the drug could be contraindicated for treatment of seizures as it can exacerbate them (https://pubmed.ncbi.nlm.nih.gov/9596203/). Finally, note that this disease is denoted as Tonic-clonic seizure in the original file but known as Seizures in MESH.

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